Phage RBP Database

UniProt accession

Q54699 [UniProt]

Protein name

Hyaluronoglucosaminidase

RBP type

TSP

Evidence DepoScope

Probability 1,00

TSP

Evidence RBPdetect2

Probability 0,90

Seq2Symm

C3 confidence 0,966

C3	0,966
C1	0,054
D3	0,034

Predicted homo-oligomer symmetry (Seq2Symm, per-class probabilities; C1 = monomer, C2 = dimer, C3 = trimer).

Protein sequence

MSENIPLRVQFKRMKAAEWARSDVILLESEIGFETDTGFARAGDGHNRFSDLGYISPLDYNLLTNKPNIDGLATKVETAQKLQQKADKETVYTKAESKQELDKKLNLKGGVMTGQLKFKPAATVAYSSSTGGAVNIDLSSTRGAGVVVYSDNDTSDGPLMSLRTGKETFNQSALFVDYKGTTNAVNIAMRHATTPNFSSALNITSGNENGSAMQLRGSEKALGTLKITHENPSIGADYDKNAARYPLILSKRQNGAGTAAQGIYINSTSGTTGKLLRIRNLSDDKFYVKSDGGFYAKETSQIDGNLKLKDPTANDHAATKAYVDKAISELKKLILKK

Physico‐chemical properties

protein length:	337 AA
molecular weight:	36452,58130 Da
isoelectric point:	9,27566
aromaticity:	0,06825
hydropathy:	-0,51543

Domain architecture

Q54699

1 337 aa

ATT 7–45 · STR 46–335 ·

ATT Attachment Domain STR Structural Domain RBD Receptor-Binding Domain CBM Carbohydrate-Binding Module LEC Lectin-like Domain ENZ Enzymatic Domain CHP Intramolecular Chaperone LNK Linker/Spacer Domain TAS Tail-Associated Structural TTP Tail Tubular Protein UNK Uncharacterized Domain Unmapped

InterPro domains

SSF69349
STR

SSF69349

IPR041352
ATT

IPR041352 IPR009860

Q54699

1337 aa

ATT Attachment Domain STR Structural Domain RBD Receptor-Binding Domain CBM Carbohydrate-Binding Module LEC Lectin-like Domain ENZ Enzymatic Domain CHP Intramolecular Chaperone LNK Linker/Spacer Domain TAS Tail-Associated Structural TTP Tail Tubular Protein UNK Uncharacterized Domain Unmapped

InterPro domain annotations

Domain ID	Category	Cluster	Start	End	Layer	Name	Pref Zone	Confidence	Evidence	Support
SSF69349	STR	SSF69349	7	335	Merged direct domain	SSF69349	Central	Low	Positional only	153 proteins / 153 hits
IPR041352	ATT	DC_0533	9	45	InterPro cluster	Major tropism determinant, N-terminal domain	Central	Medium	Text match	295 proteins / 296 hits
IPR009860	STR	DC_0236	130	295	InterPro cluster	Hyaluronidase, bacterial	C-terminal	Low	Positional only	43 proteins / 43 hits

Proteins with similar domain architecture

Segmented into three structural domains: N-terminal, central, and C-terminal.

Domain layout

Q54699

1 337 aa

Domain	Start	End	Length (AA)	Confidence
N-terminal	1	111	111	0,9861
Central domain	112	310	200	0,1270
C-terminal	311	337	26	0,9896

N-terminal Central domain C-terminal

View these domains on the 3D structure via the Color by → Tail spike option in the Tertiary structure section below.

Phage

Streptococcus pyogenes phage H10403 [NCBI] · taxon 86065

No lineage information

Host No host information

Genbank protein accession

AAA86895.1 [NCBI]

Genbank nucleotide accession

U28144 [NCBI]

CDS location

range 106 -> 1119
strand +

CDS

ATGAGTGAAAATATACCGCTGCGAGTCCAATTTAAGCGCATGAAAGCCGCCGAGTGGGCTCGTAGTGATGTCATCTTACTGGAGAGCGAGATAGGCTTTGAGACAGACACAGGTTTTGCCAGAGCAGGTGATGGGCACAATCGATTTAGTGACCTTGGATACATTAGTCCACTCGATTACAATCTACTGACTAACAAGCCAAATATTGATGGATTAGCGACAAAAGTCGAGACCGCTCAGAAACTACAACAAAAAGCAGATAAAGAGACCGTCTATACAAAAGCTGAATCGAAGCAAGAGCTTGACAAGAAATTAAATCTCAAAGGTGGCGTTATGACAGGTCAACTAAAATTTAAGCCAGCCGCCACTGTTGCTTATTCCTCGTCAACGGGTGGAGCGGTCAATATTGACTTGTCGTCTACCAGAGGTGCTGGTGTTGTTGTCTATTCTGACAATGATACCAGTGATGGGCCGTTAATGAGCTTGCGGACGGGTAAAGAGACCTTTAATCAATCGGCGCTTTTTGTCGACTATAAGGGGACAACAAATGCCGTTAATATTGCGATGCGTCACGCAACCACCCCCAATTTTTCATCGGCGCTTAATATTACTAGCGGCAATGAAAATGGTAGTGCAATGCAGCTACGAGGGTCAGAAAAAGCGCTAGGAACGCTAAAAATTACTCATGAGAACCCAAGTATTGGAGCGGATTATGATAAAAATGCGGCACGTTATCCATTGATATTGTCAAAAAGACAAAACGGTGCAGGAACAGCCGCTCAGGGAATCTACATTAACTCAACCTCAGGCACGACAGGGAAGTTGCTTAGGATTAGAAACCTTAGTGATGATAAGTTCTACGTCAAGTCTGACGGTGGTTTTTATGCCAAGGAAACTTCGCAGATTGATGGCAACCTGAAACTCAAGGACCCCACAGCGAATGATCATGCGGCAACCAAAGCTTATGTAGATAAAGCAATTTCTGAGTTAAAAAAACTCATACTAAAAAAATAG

	Description	Category	Evidence (source)
GO:0044423	virion component	Cellular Component	IEA:UniProtKB-KW (UniProt)
GO:0004415	hyalurononglucosaminidase activity	Molecular Function	IEA:UniProtKB-EC (UniProt)
GO:0045227	capsule polysaccharide biosynthetic process	Biological Process	IEA:InterPro (UniProt)
GO:0098994	symbiont entry into host cell via disruption of host cell envelope	Biological Process	IEA:UniProtKB-KW (UniProt)
GO:0098996	symbiont entry into host cell via disruption of host cell glycocalyx	Biological Process	IEA:UniProtKB-KW (UniProt)

A publication is attached to this entry, with nothing stating that an experiment backs the annotation. Treat as a lead, not as validation.

Tier	Source	Assay	Claim	Reference
Literature-linked	PubMed 7622224	literature_xref	—	PMID 7622224

Rows marked “Validated by sequence identity” come from a different entry carrying the same sequence — the experiment was not performed on this protein.

Title	Authors	Date	PMID	Source
	—	—	7622224	PubMed

Protein

Domains

Tail Spike Domain Segmentation

Taxonomy

Coding sequence (CDS)

Genome Context

Gene Ontology

Tertiary structure

Predicted Aligned Error (PAE)

Experimental validation

Literature