Protein

Experimentally validated RBP function shown
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UniProt accession
A0A219YHG0 [UniProt]
Protein name
Depolymerase 1, capsule K8-specific
RBP type
TF
Evidence GenBank
Probability 1,00
TSP
Evidence DepoScope
Probability 1,00
TSP
Evidence RBPdetect
Probability 0,91
TSP
Evidence RBPdetect2
Probability 0,90
TSP
Evidence DepoCatalog
Probability 1,00
Seq2Symm
C3 confidence 0,999
C3 0,999
C1 0,004
C6 0,000
Predicted homo-oligomer symmetry (Seq2Symm, per-class probabilities; C1 = monomer, C2 = dimer, C3 = trimer).
Protein sequence
MDQDIKTVIQYPVGATEFDIPFDYLSRKFVRVSLVADDNRRLLSNITEYRYVSKTRVKLLVETTGFDRVEIRRFTSASERIVDFSDGSVLRAADLNVSQIQSAHIAEEARDAALMAMPEDDAGNLDARNRKIVRLAPGEAGTDAINKNQLDETLGEAGGILSDFEDVRDEIIQYISKFTDDTGAVRGVSYVYNNGRALGGETGFHIDITPPPLGVPYLSINGSKQYRGYHFTYDPITGNVQGLATPLEKDDFVVATTTESVTPIEDLYASTQGASMIGTLSGSTVEERIAEVEQSVLDSIDGIRVDSFIGMTDSGAIDAAIAEALRVNSYVKFSPRVYTVDRPVILPSKTVLVGTQGLTKIVASASWNGPVVMSKDAPAGDYLTINVPSAMVYGVYIFGIIIESGWKGTTDDSRYHTECLRIYGAGTILKGVRVGKCRGDGANLGGRGLTAIDYGAPSLYSDVRADLIGKNGITIGGSSDNHTQNIVVRNAGLLEHDVYYCIGIGPGGGTRGNEYHTWHSGDAQITPLYQNRPKYGLYLAGWDTYITNGHFEGAASAQIANFGGRNQVTNVRAYSTWDQDKCTVLVAGPAFKFVGNIGAPMNNVPANRCHAFQLGTADIQVNQVEITAQVNGQKFVNYVNAGGSNSIAVRGTLGIAGASGIGTLVTGTVPDDNELTIIAEPYKGKRLGLNLILTGDKGLTCRDVNSTGQISGVNALLTGKVMLTGLSSDIPTTPGTVYVDSNGNLKVKL
Physico‐chemical
properties
protein length:749 AA
molecular weight: 80190,07140 Da
isoelectric point:5,18027
aromaticity:0,07610
hydropathy:-0,13632

Domains

View on InterPro
Domain architecture
A0A219YHG0
1 749 aa
ATT 3–127 · STR 310–655 ·
ATT Attachment Domain STR Structural Domain RBD Receptor-Binding Domain CBM Carbohydrate-Binding Module LEC Lectin-like Domain ENZ Enzymatic Domain CHP Intramolecular Chaperone LNK Linker/Spacer Domain TAS Tail-Associated Structural TTP Tail Tubular Protein UNK Uncharacterized Domain Unmapped
Proteins with similar domain architecture

Tail Spike Domain Segmentation

Segmented into three structural domains: N-terminal, central, and C-terminal.

Domain layout
A0A219YHG0
1 749 aa
Domain Start End Length (AA) Confidence
N-terminal 1 313 313 0,9975
Central domain 314 706 394 0,9882
C-terminal 707 749 42 0,8948
N-terminal Central domain C-terminal

View these domains on the 3D structure via the Color by → Tail spike option in the Tertiary structure section below.

Taxonomy

Phage
Klebsiella phage K5-4 [NCBI] · taxon 1932362
Viruses Duplodnaviria Heunggongvirae Uroviricota Caudoviricetes
Host
Klebsiella pneumoniae [NCBI] · taxon 573
cellular organisms Bacteria Pseudomonadati Pseudomonadota Gammaproteobacteria Enterobacterales

Coding sequence (CDS)

No CDS data available.

Genome Context

Gene Ontology

Description Category Evidence (source)
GO:0098015 virus tail Cellular Component IEA:UniProtKB-KW (UniProt)
GO:0098671 adhesion receptor-mediated virion attachment to host cell Biological Process IEA:UniProtKB-KW (UniProt)
GO:0098994 symbiont entry into host cell via disruption of host cell envelope Biological Process IEA:UniProtKB-KW (UniProt)
GO:0098996 symbiont entry into host cell via disruption of host cell glycocalyx Biological Process IEA:UniProtKB-KW (UniProt)

Tertiary structure

A0A219YHG0
1 / 2
Structure ID
Source
Method
Resolution
Oligomeric state

Experimental validation

Experimentally validated

A wet-lab result is recorded for this protein, or for its sequence: a solved structure, an experimental GO annotation, a UniProt ECO:0000269 assertion, or a GenBank /experiment= qualifier.

Tier Source Assay Claim Reference
Experimentally validated UniProt
A0A219YHG0
 ECO:0000269:FUNCTION:28676686 RBP Functions as a receptor binding protein (RBP) and probably mediates the attachment to the host capsular exopolysaccharides (Probable). Displays a depolymerase activity that specifically degrades the K8-type polysaccharides of Klebsiella pneumoniae capsule, which allows the phage to reach the host cell membrane and bind the entry receptor (PubMed:28676686) PMID 28676686

Rows marked “Validated by sequence identity” come from a different entry carrying the same sequence — the experiment was not performed on this protein.