Phage RBP Database

UniProt accession

A0A6B9WLW1 [UniProt]

Protein name

Endo-N-acetylneuraminidase

RBP type

TF

Evidence Phold

Probability 1,00

TSP

Evidence DepoScope

Probability 1,00

TSP

Evidence RBPdetect2

Probability 0,61

Protein sequence

MSTTITNLPETSKVNGSDYLVLDQPDKTVKSTVSNFLTDTGVVLATQLKDISGATKYPELQMSRWRDEGDPRGWGAVGDGVTDDTNAITQLLAAMPDGWIIDGRNLTFKVTTLPDISKFKNAAFVYERIVGQPLTYVSEGFFDGNLTKITDTPFYNAWTQDKTFVYDNVIYAPFMAGERHGVQNLHVAWVKSGDDGQTWSMPEWLTPIHPDYNASSANKVNYHCMSMGVCGNRLYAVIETRYLSNMRLKKAELWSRPMPYYRRPTGGITISSGSTTATIVLEKHGLKVGDAVNFSNSGATGVSGNMTVASVINKDTFTVTLASAATSNIDNTGTTWHFGTRFWDSPWEITELPDVAYSTNADLCVTETHSFTVIDDDNYTFAVGYHNGDVSPRRLGILYFNNAYSDPSSFTRRTISQEYADNAAEPCIKYYDGILYLTTRGTSTSAAGSTLAMSADLGENWNYLRFPNNVHHTNLPFAKVGNYLYIFGTERSFGEWEGEELDNRYKGTYPRTFMCKINVSAWPASLSDVQWFNITDQMYQGHIVNSACGVGSVCVKDGWLYYIFGGEDFLSPWSIGDNSKKLWYKHDGHPADLYSYRLKITEHDFVSRDFKYGATPNRTLPVSMGTDGVRHVSAPVTFDNDVQVHSLTVTGLEHDGTQQSAVRIKLDGDYGVVAKNVPIKNPSEQRLILCGGETPYVTDGSLLQLYGSNHTYPNRAVLYAPGGAYTQNNFMPYLDGQVALGGASNRWSEVYASTGTINTSDGTLKTKPTEIEDILLKAWEDIHVISYQWLSAIAEKGDSARIHFGVIAQDVRDILINYGLMDENSTDCKYAFLCYDEYPAMYDSVVTGQKEIPLFDDEGNVVIDEEGNPVTIVEDVVETIEIIPAGSRWGIRADQMFFIEMAYQRKKLKALEERLATLESK

Physico‐chemical properties

protein length:	921 AA
molecular weight:	102508,32160 Da
isoelectric point:	4,98764
aromaticity:	0,11401
hydropathy:	-0,33420

Domain architecture

A0A6B9WLW1

1 921 aa

ATT 70–141 · STR 142–759 · CHP 760–772 · RBD 773–824 · CHP 825–891 · RBD 892–921

ATT Attachment Domain STR Structural Domain RBD Receptor-Binding Domain CBM Carbohydrate-Binding Module LEC Lectin-like Domain ENZ Enzymatic Domain CHP Intramolecular Chaperone LNK Linker/Spacer Domain TAS Tail-Associated Structural TTP Tail Tubular Protein UNK Uncharacterized Domain Unmapped

InterPro domains

G3DSA:3.30.750.60
ATT

G3DSA:3.30.750.60 G3DSA:2.120.10.10 IPR044914 IPR030392

IPR036278
STR

IPR036278 SSF69349 cd10144

IPR024429
ENZ

IPR024429 IPR024428 IPR024430 IPR030392 G3DSA:3.30.2460.10 G3DSA:1.20.5.100

IPR001724
Unmapped

IPR001724 IPR001724 IPR024427 IPR001724 IPR001724 IPR001724 IPR001724 IPR001724 G3DSA:1.20.5.1240 Coil

IPR023366
STR

IPR023366

IPR001724
Unmapped

IPR001724

A0A6B9WLW1

1921 aa

ATT Attachment Domain STR Structural Domain RBD Receptor-Binding Domain CBM Carbohydrate-Binding Module LEC Lectin-like Domain ENZ Enzymatic Domain CHP Intramolecular Chaperone LNK Linker/Spacer Domain TAS Tail-Associated Structural TTP Tail Tubular Protein UNK Uncharacterized Domain Unmapped

Novel HMM domains (de novo, PhaRBP-HMM)

Experimental de novo families on regions without InterPro annotation. Separate from the InterPro architecture above.

DC_0079
ATT

DC_0079

A0A6B9WLW1

1921 aa

InterPro domain annotations

Domain ID	Category	Cluster	Start	End	Layer	Name	Pref Zone	Confidence	Evidence	Support
G3DSA:3.30.750.60	ATT	G3DSA:3.30.750.60	70	141	Merged direct domain	G3DSA:3.30.750.60	N-terminal	Low	Positional only	2 proteins / 2 hits
IPR036278	STR	IPR036278	75	606	Merged direct domain	Sialidase superfamily	Central	Low	Positional only	56 proteins / 56 hits
IPR024429	ENZ	DC_0802	76	142	InterPro cluster	Endosialidase, N-terminal extension domain	N-terminal	High	Text match	84 proteins / 84 hits
G3DSA:2.120.10.10	STR	G3DSA:2.120.10.10	142	600	Merged direct domain	G3DSA:2.120.10.10	Central	Low	Positional only	42 proteins / 42 hits
IPR024428	ENZ	DC_0114	143	600	InterPro cluster	Endosialidase, beta-propeller domain	Central	High	Text match	92 proteins / 92 hits
IPR001724	Unmapped	-	144	168	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	214	242	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR024427	ENZ	DC_0382	259	341	InterPro cluster	Endosialidase, beta-barrel domain	Central	High	Text match	86 proteins / 86 hits
IPR023366	STR	IPR023366	262	342	Merged direct domain	ATP synthase subunit alpha, N-terminal domain-like superfamily	Central	Low	Positional only	44 proteins / 44 hits
IPR001724	Unmapped	-	333	356	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	412	438	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	490	516	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	548	572	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR044914	RBD	IPR044914	603	759	Merged direct domain	Endosialidase, C-terminal domain superfamily	C-terminal	Low	Positional only	39 proteins / 39 hits
IPR024430	ENZ	DC_0521	603	759	InterPro cluster	Endosialidase, C-terminal domain	C-terminal	High	Text match	95 proteins / 95 hits
SSF69349	STR	SSF69349	607	759	Merged direct domain	SSF69349	Central	Low	Positional only	153 proteins / 153 hits
IPR001724	Unmapped	-	652	678	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	684	711	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR030392	CHP	DC_0088	760	921	InterPro cluster	Intramolecular chaperone auto-processing domain	C-terminal	High	Text match	3502 proteins / 3959 hits
cd10144	CHP	DC_0088	760	907	InterPro cluster	cd10144	C-terminal	High	Text match	3502 proteins / 3959 hits
IPR030392	CHP	DC_0088	760	819	InterPro cluster	Intramolecular chaperone auto-processing domain	C-terminal	High	Text match	3502 proteins / 3959 hits
G3DSA:1.20.5.1240	RBD	G3DSA:1.20.5.1240	773	824	Merged direct domain	G3DSA:1.20.5.1240	C-terminal	Low	Positional only	1 proteins / 1 hits
G3DSA:3.30.2460.10	Unmapped	-	825	891	Gene3D	None	-	-	-	-
G3DSA:1.20.5.100	RBD	G3DSA:1.20.5.100	892	921	Merged direct domain	G3DSA:1.20.5.100	C-terminal	Low	Positional only	8 proteins / 8 hits
Coil	Unmapped	-	901	921	Coils	Coil	-	-	-	-

Proteins with similar domain architecture

Segmented into three structural domains: N-terminal, central, and C-terminal.

Domain layout

A0A6B9WLW1

1 921 aa

Domain	Start	End	Length (AA)	Confidence
N-terminal	1	84	84	0,9848
Central domain	85	420	337	0,8902
C-terminal	421	921	500	0,5907

N-terminal Central domain C-terminal

View these domains on the 3D structure via the Color by → Tail spike option in the Tertiary structure section below.

Phage

Escherichia phage nepoznato [NCBI] · taxon 2696431

Uroviricota Caudoviricetes Stephanstirmvirinae Phapecoctavirus nepoznato

Host

Escherichia coli K-12 [NCBI] · taxon 83333

Bacteria Proteobacteria Gammaproteobacteria Enterobacteriales Enterobacteriaceae Escherichia

No CDS data available.

	Description	Category	Evidence (source)
GO:0098015	virus tail	Cellular Component	IEA:UniProtKB-KW (UniProt)
GO:0016996	endo-alpha-(2,8)-sialidase activity	Molecular Function	IEA:InterPro (UniProt)

Protein

Domains

Tail Spike Domain Segmentation

Taxonomy

Coding sequence (CDS)

Genome Context

Gene Ontology

Tertiary structure

Predicted Aligned Error (PAE)