Protein

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UniProt accession
A0A8S5M9I4 [UniProt]
Protein name
Cytosine-specific methyltransferase
RBP type
TSP
Evidence DepoScope
Probability 1,00
Protein sequence
MERNKLTLGSLFDGSGGFPLGGLLSGITPVWASEIEPFPIRVTTKRLPFMKHYGDVSRMDGGKIEPVDVITFGSPCQDMSIAGRREGLDGSRSSLFYEAVRIVKEMRCATDGRYPRYIVWENVPGAFSSNKGADFQSVLEEICSVKGYEIHTPRPEKWTTAGEIVADNFSLAWRVFDAQYWGVPQRRKRIYLVADFAGGSAGKILFESEGVSGYTPQGFRSWQGAAGTSEKGAGAAGCVCLNDQGGNRMDVTDGVTCTLRAEAHHPPCVMESAGFCTEHSAHSRSIGYEEETPPTLRAGTVPAAVYENHSQDTRYTGPLETAPTVMSTYGTGGNNQPFVVETPKTLKIRSGCEGGGKGALIQDNKSATLGCNNDQTVFVPFVKGTRPHSSDEGQQWKDGTVANTLNTHDVGESRCNELAVKVYGICSKQSHAMQSDNPHSGFYEADTSRCLDANGGNPSCNQGGMAVVAVQGSMIGRSDKNGPQGSGVNEDVSFTLDATDRHAVAYGIDRATYNMGRNAKFGITVETEIEPTMVSKGPGAVGQPIYHSSKSSFHTNFTDDDVTETLVATDFKDPPTVSKEPDYIVRRLTPTECARLQGFPGWWCDALGTDEPTENEIEFWTEVFETHRRVMGTSSKPKSRNQIIKWLKDPHSDSAEYKMWGNGVALPNVCFVLSGIVYYAQLSGE
Physico‐chemical
properties
protein length:685 AA
molecular weight: 74389,09190 Da
isoelectric point:5,50658
aromaticity:0,08759
hydropathy:-0,46380

Domains

Domains [InterPro]
IPR029063
STR
1–214
IPR029063 G3DSA:3.90.120.30
IPR029063
STR
3–674
IPR029063
IPR001525
ATT
6–630
IPR001525
IPR001525
ATT
7–23
IPR001525 IPR050390
IPR001525
ATT
8–194
IPR001525
IPR001525
ATT
10–194
IPR001525
IPR018117
Unmapped
68–80
IPR018117 IPR001525 IPR001525
A0A8S5M9I4
1 685
Architecture
ATT
STR
ATT 1-630 | STR 631-674 |
Legend: ATT STR RBD CBM LEC ENZ CHP LNK TAS TTP UNK Unmapped

Tail Spike Domain Segmentation

Tail Spike Domain Segmentation

This protein has been segmented into three structural domains: N-terminal, central domain, and C-terminal.

Domain Layout
N-terminal
Central
C-terminal
A0A8S5M9I4
1 685
Domain Start End Length (AA) Confidence
N-terminal 1 231 231 0,1278
Central domain 232 578 348 0,8252
C-terminal 579 685 106 0,6801
Legend: N-terminal Central domain C-terminal
3D Structure with Domain Coloring

The structure is colored according to the domain segmentation: N-terminal (blue), Central (green), C-terminal (pink).

Domain Coloring
N-terminal
1-231
Central
232-578
C-terminal
579-685

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. cte421
[NCBI] 		2826402 Uroviricota > Caudoviricetes >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
Genbank protein accession
DAD78906.1 [NCBI]
Genbank nucleotide accession
BK014854 [NCBI]
CDS location
range 14211 -> 16268
strand +
CDS
ATGGAACGGAATAAACTGACCCTCGGCAGCCTGTTTGACGGTTCCGGCGGTTTCCCTCTTGGCGGCTTGCTCTCCGGCATTACCCCCGTTTGGGCATCGGAGATCGAGCCGTTCCCCATCCGGGTGACCACAAAGCGGCTTCCGTTTATGAAGCATTACGGCGATGTCTCCCGGATGGACGGTGGGAAGATTGAGCCGGTGGATGTCATTACCTTCGGCAGCCCTTGCCAGGACATGAGCATCGCGGGCCGGAGGGAAGGTCTGGACGGCTCCCGCTCCAGCCTTTTCTATGAAGCCGTCCGGATCGTAAAGGAAATGAGGTGTGCAACTGATGGCAGATATCCAAGGTATATCGTCTGGGAGAACGTCCCCGGCGCGTTCAGTTCCAACAAGGGTGCGGACTTCCAGTCCGTCCTCGAAGAGATCTGCTCGGTCAAAGGATACGAAATTCATACTCCTCGACCTGAGAAATGGACGACCGCCGGAGAGATCGTGGCAGATAATTTCAGTCTCGCATGGCGGGTATTTGATGCGCAGTACTGGGGAGTTCCCCAACGCAGAAAACGCATCTACCTTGTCGCAGATTTTGCAGGCGGGAGTGCCGGAAAAATACTATTTGAGTCCGAAGGCGTGTCTGGGTATACTCCGCAGGGCTTCCGTTCGTGGCAAGGAGCTGCCGGAACTTCTGAGAAAGGCGCTGGAGCGGCAGGCTGCGTCTGCCTGAACGATCAGGGCGGAAACCGCATGGATGTGACGGACGGTGTCACCTGCACCCTCCGGGCGGAGGCCCACCATCCTCCCTGCGTGATGGAATCTGCGGGCTTTTGCACCGAGCATTCCGCACACAGCCGCTCCATCGGGTACGAGGAAGAAACCCCTCCCACTCTCCGGGCGGGGACGGTGCCGGCGGCGGTCTATGAGAACCATAGCCAGGACACCAGATACACCGGTCCATTGGAAACAGCGCCCACGGTCATGTCTACTTACGGAACAGGCGGCAACAATCAGCCCTTCGTGGTGGAAACGCCAAAGACGCTGAAAATCCGCTCCGGCTGTGAGGGTGGTGGCAAGGGTGCGCTGATCCAGGACAACAAATCTGCCACCCTCGGATGCAACAACGACCAGACGGTGTTTGTGCCGTTTGTGAAAGGCACCCGCCCCCACTCTTCCGATGAAGGGCAACAGTGGAAAGACGGAACCGTGGCGAATACGCTGAACACCCATGATGTGGGCGAATCCAGATGTAATGAGCTGGCTGTCAAGGTCTACGGCATCTGCTCCAAGCAGAGCCACGCCATGCAGTCGGACAATCCTCACAGCGGTTTTTATGAAGCGGATACCTCCCGCTGCCTGGACGCAAACGGCGGCAATCCCTCCTGCAACCAGGGCGGTATGGCTGTGGTGGCTGTGCAAGGCTCTATGATCGGAAGGTCTGACAAGAACGGTCCCCAGGGCAGCGGCGTGAACGAGGATGTGTCCTTCACGCTGGACGCCACCGACCGCCATGCGGTAGCTTACGGAATCGACCGCGCCACATACAACATGGGACGGAACGCCAAGTTCGGAATTACAGTGGAAACGGAAATCGAGCCAACGATGGTGTCCAAAGGACCGGGAGCGGTCGGGCAGCCTATCTACCATTCAAGCAAGAGTTCCTTCCACACCAATTTTACGGATGATGATGTGACGGAAACGTTGGTCGCTACAGATTTCAAAGATCCGCCTACGGTATCTAAGGAGCCTGACTACATCGTCCGCAGACTGACGCCTACCGAATGCGCCAGACTGCAGGGGTTCCCGGGCTGGTGGTGCGATGCGCTTGGAACTGATGAGCCGACCGAGAATGAGATCGAGTTCTGGACAGAGGTGTTTGAAACACACCGAAGGGTCATGGGAACCTCCTCCAAGCCAAAGAGCCGCAATCAGATCATTAAGTGGCTGAAAGACCCCCACTCCGACTCTGCGGAATACAAGATGTGGGGCAACGGCGTGGCACTGCCTAACGTCTGTTTTGTGCTTTCCGGCATCGTGTACTATGCACAGTTATCCGGCGAATGA

Genome Context

Genome Context

Gene Ontology

Description Category Evidence (source)
GO:0003886 DNA (cytosine-5-)-methyltransferase activity Molecular Function IEA:UniProtKB-EC (UniProt)
GO:0003677 DNA binding Molecular Function IEA:TreeGrafter (UniProt)
GO:0032259 methylation Biological Process IEA:UniProtKB-KW (UniProt)
GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation Biological Process IEA:TreeGrafter (UniProt)
GO:0099018 symbiont-mediated evasion of host restriction-modification system Biological Process IEA:UniProtKB-KW (UniProt)
GO:0052170 symbiont-mediated suppression of host innate immune response Biological Process IEA:UniProtKB-KW (UniProt)

Tertiary structure

PDB ID
b12db15fb61e820f487e3777ab02042d6103397e7db36b57dff047f6be17b364
ColabFold
Source ColabFold
Method ColabFold
Resolution 0,6134
Oligomeric State monomer
Download PDB
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50