Protein

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UniProt accession

A0A9E7MRE5 [UniProt]

Protein name

receptor protein-tyrosine kinase

RBP type

TSP

Evidence DepoScope

Probability 1,00

Evidence RBPdetect2

Probability 0,53

Protein sequence

MTDYTSILHLPQVGSNQEQKEATINTAIAILEASANDTLVLSLAAGDVTLNTDQFTKYFLHQFTGHTVARQVTIPATPRWFAVENRGTAPIVFKVAGASGLTVELPANRIGLVVADGSNIRFVVPDPISGMGLLRDLSDVDGLPTDGQLLRYDASTAQWKPWTWTAAFTQLSDTPSSLGGSAGKLVAVNAAGNRLEFITSAANINSFVDLDDTPNSYASAANRHVVVNASGTALTFARPYLRENSDFPSSYNTHARKFLRVNAAADAVEFGNPAVADLMDGPGAPTINEALLYVRVNAAGTGWEYVTGTGGPVNFTELHDTPSNFTGHKGKLVRVGQDEDQLIFSELKLTELSDTPNNYTDAAHKILKVNATQSGVVFGTLKVEELSDGPGPMAAAQRGLYVRVNATNTGLEYVKPALSELSGVPSFAGQGGKFVRVNDSETGLDFAINAMDMAFIGLSDTPVNYSGSQNKFVAVNAQGTGLVFVPPPTGGGGGGGPYSLDQITDVDAPDPAAGQVLTFRDGWWRPETPTGGVIGVTALSELTDVNFTIKAPEEGDVLTFESGFWVAKPANATPIPQALDDLTDVDLSEGALTNGEVLTYWDGKWIHAPVQVPSGDGLRFGEHRDWRLFFRTADTPPLEIAEFVLRAGSGLPQLAVGGTPSANADAGVGFESALAFDGDPATFWRSGADGADQTWLRYTFAEPQEVNAVSLTFGAVRQLPITWAMQFSDDGGLTWITAWSETRAFGWNAGETVDTEPARAKLAFAMLSDSPGAMSAHPGKFVRVDEDGVRLEYVELPIPATSLEELTDVQFTAPPEEDQVLTFKDGIWQPKDPATSVIPEMALNDLTDVDTAGQQEGDLLGRRAGRWVSLTSPIDYGRHAYWRVVVDDTAAYPGTTTVVVAEVVMRDVPGGPQRATGGTAIGTGGNINGAFDGTVGDAWTAYLPDAWIGYHFAAPVSLQEVALTASSVAGWAPNYSPEAFRVQYSDDGVAWYTAWSVTGQTAWAASQTRVYTRPGLTTRFLDDVDTPDTYVGQAGKLVHVKTDESGLEFVDKPVVPEDLGDLGDVDVVTTPPGADSVLIYYPQIDLPGVWRPGLLHLDMLSDVHVPYDPVNGQVLTWVDTGVEGSGRWEARTPENGGGPGTEYPISITDDRWIESGEGAPTWPMPSGSLYMRHDPGDLMVSRATPRLAPRVVQEYGRIVENAGAVSWGYAENPIAGNWLILIYASGSNGAVTLAPGWTTVNQGVGADLSVTVAYRKVQAAEDWPLDITTQSGPEDAYAIYEVSGLGENWADFYQAAQAVGSTAGSFAPTPYTTPATTPFTFAVGAMFQLGGAAPVATDGEFFNEPVTDSTGTLSIAAATNYGTEPTQDLTMNGTVAAGSSHWAYGVLYVDAVRSYGDDLEPSWARFLVEGEGGAKSLDELTDVDLTVPPQNGQALVYRDGSWKAEAVEGAGLDPDRQQIALLIVNPGAEDGMTGWTNTAGAFTSETSAGSLGAPFEGTRIFRATQNTSPCEMAQTIAIDAALWDYIDIGRGSVDVAFRYGRVNTDGSTALVTLEALNETGTLITSSASPAYTTTTTWQLGSVHHALPPLTRSVRLVVRSTRTGTMNYGAFDAFSGLIKIASAHPALSDLPDVGPWTTAPVAGQVLTYLGGVWMNETPSAGNLDALTDVTLTTPAAGQILVYRAGQWINESPQGTGVPSNGSHAHWRLLIDQTDGDASQVGIQDIWFRQTKTGPQLATGGTATASSSQSSSQGPEGAFDGVTGGAWFSAAGNPVGQWIAYAFPAPVEVRYLDLKGSQDYPTRSPRAFKVQWSDDGSTWTTAWTVTGQTGWAPNQTRQFHAPMDLFFTDLADAPPSYIGQAGKPVRVKSDESGMEFGHDSLGDLTDVSFPTAPSDGEVLTRVGGQWRSAPPTTGAENTSNWTAPWRGALVERTTDLTSVTFPTTVPWQAETSDTDGFFTTSAPTRLTIPSGITKVRVTAFVAFTSVAGAGSNYADIYRNGVALKVTRTTARNSSLNGYINNEMTVSTPVISVVPGDYFEIRANSNIAGVNSILARSWAELEVIESDYAINPPEALDDLSDVTLGTPVQDYVLTYDNGVWRAKELPASSGGTVYMADIGDVEMPVGGPGENDVLRYQAGKWRPLPAGSADGLFLDNAMIGSGQGGPTTPRPSGSLYIDEVTGQISQSLKDVPTVAPAPTVVQHILSDAYNSATSAQPITATLPAAPTAGNWLVALLCDQTLATAGSGWTLLPGSPVSGSTRVRPSVAYKQAVSAEPAAQTPFVSGGGQIGAGAMVIYEIAGMSTWSESFQGVVWEDDTSYSSAASGMARAPLTARALHDGLGLGLYVTRPNSSTLTPDAPWTTLSSGVAPTGGGNRVYVATSAAAAAGTSIAPKATFTGASEAGYVTILLDNGPATFEEGWRPYTGNIALDDLTDVTSTAPGNGQVLTYRDGAWSPEAAEGEFSGTGEPTATAPLGKVYQQRDSAGNAWVSTLVPAGSTAPTYYTATGTRQSFVVGPQVSSLTFKLWGGGGGTGRYSTGGNPAAGGFTQVTFAVNEGDLIELDVPSGGQGGYRSNYGGAGGWPDGGFGGLGDTAGGGGGGSARVWRNGVLMAVAGGGGGGSGYTATNAGAGGGDTGQSSSTSNGGTGGTQTAGGYDGNDSASAPKRGGYLQGGQGTAAVDRFTSSTDDGGGGGGGYYGGGGGGGDGQPGGGGSGYLNLAAGATGVTEAGDRLVPPHTADEHYQVNVGVGYPTENVTGPAPNGGDGLIVVLAPPYVQGWRRLATSDDVDALALMDLLKVTLQGDGDPDYLLTAQDRRAYRKITSSADKTVTIPPNSDVPFPIGASFSLQRGGIGRVTILAGSGVALEYPDDMQPRLRRQNSVASLVQIATNVWSLFGDLEPV

Physico‐chemical properties

protein length:	2898 AA
molecular weight:	302878,82270 Da
isoelectric point:	4,41601
aromaticity:	0,08834
hydropathy:	-0,17374

Domains

Domains [InterPro]

DC_0755
ATT
1–442

DC_0755 DC_1385 IPR000421 IPR000421 DC_0349 IPR000421 DC_0755 DC_0450

DC_0349
ATT
532–691

DC_0349 G3DSA:2.60.120.260 G3DSA:2.60.120.260 G3DSA:2.60.120.260 IPR055163

IPR008979
STR
657–744

IPR008979 IPR008979 DC_1385

G3DSA:2.60.120.260
STR
658–784

G3DSA:2.60.120.260 DC_0349 IPR008979

IPR000421
RBD
669–748

IPR000421 IPR000421

DC_0349
ATT
687–946

DC_0349

A0A9E7MRE5

1 2898

Architecture

ATT

STR

ATT 1-442 | ATT 446-2346 | STR 2417-2834 |

Legend: ATT STR RBD CBM LEC ENZ CHP LNK TAS TTP UNK Unmapped

Domains [InterPro]

Domain ID	Category	Cluster	Start	End	Layer	Name	Pref Zone	Confidence	Evidence	Support
DC_0755	ATT	DC_0755	1	442	Novel HMM	DC_0755	N-terminal	Low	Positional only	28 proteins / 28 hits
DC_1385	ATT	DC_1385	446	534	Novel HMM	DC_1385	N-terminal	Low	Positional only	25 proteins / 25 hits
DC_0349	ATT	DC_0349	532	691	Novel HMM	DC_0349	N-terminal	Low	Positional only	13 proteins / 13 hits
IPR000421	RBD	DC_0058	633	745	InterPro cluster	Coagulation factor 5/8, C-terminal domain	C-terminal	Low	Positional only	33 proteins / 66 hits
IPR008979	STR	IPR008979	657	744	Merged direct domain	Galactose-binding-like domain superfamily	Central	Low	Positional only	24 proteins / 24 hits
G3DSA:2.60.120.260	STR	G3DSA:2.60.120.260	658	784	Merged direct domain	G3DSA:2.60.120.260	Central	Low	Positional only	264 proteins / 264 hits
IPR000421	RBD	DC_0058	669	748	InterPro cluster	Coagulation factor 5/8, C-terminal domain	C-terminal	Low	Positional only	33 proteins / 66 hits
DC_0349	ATT	DC_0349	687	946	Novel HMM	DC_0349	N-terminal	Low	Positional only	13 proteins / 13 hits
IPR000421	RBD	DC_0058	896	1021	InterPro cluster	Coagulation factor 5/8, C-terminal domain	C-terminal	Low	Positional only	33 proteins / 66 hits
G3DSA:2.60.120.260	STR	G3DSA:2.60.120.260	912	1022	Merged direct domain	G3DSA:2.60.120.260	Central	Low	Positional only	264 proteins / 264 hits
IPR008979	STR	IPR008979	922	1001	Merged direct domain	Galactose-binding-like domain superfamily	Central	Low	Positional only	24 proteins / 24 hits
DC_0349	ATT	DC_0349	941	1244	Novel HMM	DC_0349	N-terminal	Low	Positional only	13 proteins / 13 hits
DC_0349	ATT	DC_0349	1240	1607	Novel HMM	DC_0349	N-terminal	Low	Positional only	13 proteins / 13 hits
G3DSA:2.60.120.260	STR	G3DSA:2.60.120.260	1462	1614	Merged direct domain	G3DSA:2.60.120.260	Central	Low	Positional only	264 proteins / 264 hits
DC_1385	ATT	DC_1385	1537	1993	Novel HMM	DC_1385	N-terminal	Low	Positional only	25 proteins / 25 hits
IPR000421	RBD	DC_0058	1728	1819	InterPro cluster	Coagulation factor 5/8, C-terminal domain	C-terminal	Low	Positional only	33 proteins / 66 hits
G3DSA:2.60.120.260	STR	G3DSA:2.60.120.260	1730	1853	Merged direct domain	G3DSA:2.60.120.260	Central	Low	Positional only	264 proteins / 264 hits
IPR008979	STR	IPR008979	1733	1829	Merged direct domain	Galactose-binding-like domain superfamily	Central	Low	Positional only	24 proteins / 24 hits
IPR000421	RBD	DC_0058	1741	1840	InterPro cluster	Coagulation factor 5/8, C-terminal domain	C-terminal	Low	Positional only	33 proteins / 66 hits
DC_0755	ATT	DC_0755	1946	2346	Novel HMM	DC_0755	N-terminal	Low	Positional only	28 proteins / 28 hits
DC_0450	STR	DC_0450	2417	2834	Novel HMM	DC_0450	Central	Low	Positional only	24 proteins / 24 hits
IPR055163	STR	DC_0678	2520	2715	InterPro cluster	ALK/LTK-like, glycine-rich domain	Central	Low	Positional only	4 proteins / 4 hits

Tail Spike Domain Segmentation

This protein has been segmented into three structural domains: N-terminal, central domain, and C-terminal.

Domain Layout

N-terminal

Central

C-terminal

A0A9E7MRE5

1 2898

Domain	Start	End	Length (AA)	Confidence
N-terminal	1	2521	2521	0,6925
Central domain	2522	2794	274	0,4318
C-terminal	2795	2898	103	0,1781

Note: Constraints were applied during segmentation.
Fixed 29 C-terminal predictions appearing before Central domain

Legend: N-terminal Central domain C-terminal

3D Structure with Domain Coloring

The structure is colored according to the domain segmentation: N-terminal (blue), Central (green), C-terminal (pink).

Domain Coloring

N-terminal
1-2521

Central
2522-2794

C-terminal
2795-2898

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Brevundimonas phage vB_BpoS-Kikimora [NCBI]	2948601	Uroviricota > Caudoviricetes > Jeanschmidtviridae > Kikimoravirus kikimora >
Host	Brevundimonas pondensis [NCBI]	2774189	cellular organisms > Bacteria > Pseudomonadati > Pseudomonadota > Alphaproteobacteria > Caulobacterales

Coding sequence (CDS)

No CDS data available.

Genome Context

Gene Ontology

	Description	Category	Evidence (source)
GO:0005886	plasma membrane	Cellular Component	IEA:UniProtKB-SubCell (UniProt)
GO:0005524	ATP binding	Molecular Function	IEA:UniProtKB-KW (UniProt)
GO:0004714	transmembrane receptor protein tyrosine kinase activity	Molecular Function	IEA:UniProtKB-EC (UniProt)

Tertiary structure

PDB ID

671297a80784c1eb38962158fa3dd43bc85a94f854399653f9f4c68655da20d0

AlphaFold3

Source AlphaFold3

Method AlphaFold3

Resolution 0,6673

Oligomeric State monomer

Download PDB

Model Confidence

Very high
pLDDT > 90

High
90 > pLDDT > 70

Low
70 > pLDDT > 50

Very low
pLDDT < 50

Protein

Domains

Domains [InterPro]

Domains [InterPro]

Tail Spike Domain Segmentation

Tail Spike Domain Segmentation

3D Structure with Domain Coloring

Domain Coloring

Taxonomy

Coding sequence (CDS)

Coding sequence (CDS)

Genome Context

Genome Context

Gene Ontology

Tertiary structure

Predicted Aligned Error (PAE)

Model Confidence