Protein

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UniProt accession

O80102 [UniProt]

Protein name

Endo-N-acetylneuraminidase

RBP type

Evidence Phold

Probability 1,00

TSP

Evidence DepoScope

Probability 1,00

TSP

Evidence RBPdetect

Probability 0,90

TSP

Evidence RBPdetect2

Probability 0,95

Protein sequence

MSSGCGDVLSLADLQTAKKHQIFEAEVITGKSGGVAGGADIDYATNAVTGQTQKTLPAVLRDAGFKLADFDFTSGGTLSANDRNTAVLWPSSSGGDGDWYYWLGALPKIIPASSSPQSTGGVADGAWRPVGSVILRQQISDVNGAILYPDLHMARWKDEYDPRAWGAVGDGVTDDTQSIFNVLAASPNNWIIDGRGLTYKVSQLPDISKFKNAAFVYERVAGQPLTYVADGFFNGSLTKVTDTPFYNAWTQDKTFVYDHVIYAPFMAGERHGVQNLHVAWVRSGDDGQTWSMPEWLTPIHADYNASVSADRVNYHCMSMGTCGNRLYAVIETRYLSNMRMKKAELWSRPMPYFRHPTGGITISSGSTTATIVIENHGLKAGDAVNFSNTAATGVSGNMTVASIINRNTFTVTLSSPAGSTINNAGVTWNFATRFWDSPWEITELPEVAYSTNADLCVTETHSFAVIDDANYTIAVGYHNDDVSPRRLGVLYFSNVYDNPGVFVRRTVAQAYADNASEPCVKSYGGVLYLTTRGTLPTSPGSTLAMSTDSGQNWSYLRFPNNVHHSNLPFAKVGDYLYIFGTERAFGEWEGGAPDSRYEGSYPRTFMCKVNVSSWPSSLDDVQWFNITDQIYQGHIVNTAVGVGSVCVKDGWLYYIFGGEDFFSPWSIGDNSAKLWYKHDGHPADLYSYRIKIEDHPYVSRDFKYGATPNRTIPVAMGVDGVRHVEAPLTFDNDVSVYSLHVTGLEYDGTQQSAVRARFDGDYGLISKTVPTKTPSRQRLIVSGGDGASSSDGALLQLYGSNHATPNRAIMYASGGFYSYNNFLPYLDSQVSLGSASNRWTTVYATTGTINTSDGTLKTNKEEIEEQLLTAWEDIHVISFKWLESLAIKGDTARIHFGVIAQDVRDILVKHGLMEKDSTDCKYAFLCYDSIEAAYDIDEYGQTVQVSPPGGRWGVRADQMFFIEIAYQRKKMREFEKRLAALEDK

Physico‐chemical properties

protein length:	984 AA
molecular weight:	108281,33740 Da
isoelectric point:	5,34681
aromaticity:	0,11890
hydropathy:	-0,28659

Domains

Domains [InterPro]

DC_0018
ATT
1–248

DC_0018 IPR001724 IPR024427 IPR001724 IPR001724 IPR001724 IPR024430 IPR036388

G3DSA:2.10.10.80
ATT
65–141

G3DSA:2.10.10.80 G3DSA:3.30.750.60 G3DSA:2.120.10.10 IPR044914 IPR030392 Coil

IPR040775
RBD
97–131

IPR040775 IPR036278 SSF69349 IPR030392

IPR024429
ENZ
167–233

IPR024429 IPR024428 IPR001724 IPR001724 cd10144

IPR036278
STR
180–698

IPR036278

IPR001724
Unmapped
235–259

IPR001724 IPR023366

IPR001724
Unmapped
425–448

IPR001724

O80102

1 984

Architecture

ATT

STR

RBD

ATT 1-248 | STR 249-851 | RBD 852-984

Legend: ATT STR RBD CBM LEC ENZ CHP LNK TAS TTP UNK Unmapped

Domains [InterPro]

Domain ID	Category	Cluster	Start	End	Layer	Name	Pref Zone	Confidence	Evidence	Support
DC_0018	ATT	DC_0018	1	248	Novel HMM	DC_0018	N-terminal	Low	Positional only	154 proteins / 154 hits
G3DSA:2.10.10.80	ATT	G3DSA:2.10.10.80	65	141	Merged direct domain	G3DSA:2.10.10.80	N-terminal	Low	Positional only	383 proteins / 383 hits
IPR040775	RBD	DC_0821	97	131	InterPro cluster	Tail spike TSP1/Gp66, N-terminal domain	Central	High	Text match	1281 proteins / 1285 hits
G3DSA:3.30.750.60	ATT	G3DSA:3.30.750.60	161	232	Merged direct domain	G3DSA:3.30.750.60	N-terminal	Low	Positional only	2 proteins / 2 hits
IPR036278	STR	IPR036278	166	698	Merged direct domain	Sialidase superfamily	Central	Low	Positional only	56 proteins / 56 hits
IPR024429	ENZ	DC_0802	167	233	InterPro cluster	Endosialidase, N-terminal extension domain	N-terminal	High	Text match	84 proteins / 84 hits
IPR036278	STR	IPR036278	180	698	Merged direct domain	Sialidase superfamily	Central	Low	Positional only	56 proteins / 56 hits
G3DSA:2.120.10.10	STR	G3DSA:2.120.10.10	233	692	Merged direct domain	G3DSA:2.120.10.10	Central	Low	Positional only	42 proteins / 42 hits
IPR024428	ENZ	DC_0114	234	693	InterPro cluster	Endosialidase, beta-propeller domain	Central	High	Text match	92 proteins / 92 hits
IPR001724	Unmapped	-	235	259	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	306	334	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR024427	ENZ	DC_0382	351	433	InterPro cluster	Endosialidase, beta-barrel domain	Central	High	Text match	86 proteins / 86 hits
IPR023366	STR	IPR023366	354	434	Merged direct domain	ATP synthase subunit alpha, N-terminal domain-like superfamily	Central	Low	Positional only	44 proteins / 44 hits
IPR001724	Unmapped	-	425	448	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	504	530	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	582	608	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	640	664	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR024430	ENZ	DC_0521	694	851	InterPro cluster	Endosialidase, C-terminal domain	C-terminal	High	Text match	95 proteins / 95 hits
IPR044914	RBD	IPR044914	695	851	Merged direct domain	Endosialidase, C-terminal domain superfamily	C-terminal	Low	Positional only	39 proteins / 39 hits
SSF69349	STR	SSF69349	699	851	Merged direct domain	SSF69349	Central	Low	Positional only	153 proteins / 153 hits
IPR001724	Unmapped	-	744	770	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	776	803	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR036388	RBD	IPR036388	852	980	Merged direct domain	Winged helix-like DNA-binding domain superfamily	C-terminal	Low	Positional only	96 proteins / 96 hits
IPR030392	CHP	DC_0088	852	912	InterPro cluster	Intramolecular chaperone auto-processing domain	C-terminal	High	Text match	3502 proteins / 3959 hits
IPR030392	CHP	DC_0088	852	984	InterPro cluster	Intramolecular chaperone auto-processing domain	C-terminal	High	Text match	3502 proteins / 3959 hits
cd10144	CHP	DC_0088	852	970	InterPro cluster	cd10144	C-terminal	High	Text match	3502 proteins / 3959 hits
Coil	Unmapped	-	964	984	Coils	Coil	-	-	-	-

Tail Spike Domain Segmentation

This protein has been segmented into three structural domains: N-terminal, central domain, and C-terminal.

Domain Layout

N-terminal

Central

C-terminal

O80102

1 984

Domain	Start	End	Length (AA)	Confidence
N-terminal	1	176	176	0,9930
Central domain	177	512	337	0,8909
C-terminal	513	984	471	0,5832

Legend: N-terminal Central domain C-terminal

3D Structure with Domain Coloring

The structure is colored according to the domain segmentation: N-terminal (blue), Central (green), C-terminal (pink).

Domain Coloring

N-terminal
1-176

Central
177-512

C-terminal
513-984

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Phage #D [NCBI]	77920	Viruses > unclassified bacterial viruses >
Host	No host information

Coding sequence (CDS)

No CDS data available.

Genome Context

Gene Ontology

	Description	Category	Evidence (source)
GO:0016996	endo-alpha-(2,8)-sialidase activity	Molecular Function	IEA:InterPro (UniProt)

Tertiary structure

PDB ID

63fcc343000c95efa285882f9dc2519c5b7a05eefcb7140348e0bc701b059dee

ESMFold

Source ESMFold

Method ESMFold

Resolution 0,6555

Oligomeric State monomer

Download PDB

Model Confidence

Very high
pLDDT > 90

High
90 > pLDDT > 70

Low
70 > pLDDT > 50

Very low
pLDDT < 50

Literature

Title	Authors	Date	PMID	Source
	—	—	16232819	PubMed

Protein

Domains

Domains [InterPro]

Domains [InterPro]

Tail Spike Domain Segmentation

Tail Spike Domain Segmentation

3D Structure with Domain Coloring

Domain Coloring

Taxonomy

Coding sequence (CDS)

Coding sequence (CDS)

Genome Context

Genome Context

Gene Ontology

Tertiary structure

Predicted Aligned Error (PAE)

Model Confidence

Literature