Protein

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UniProt accession

A0AAE8Y2R9 [UniProt]

Protein name

Endo-N-acetylneuraminidase

RBP type

Evidence Phold

Probability 1,00

TSP

Evidence DepoScope

Probability 1,00

TSP

Evidence RBPdetect

Probability 0,91

TSP

Evidence RBPdetect2

Probability 0,94

Protein sequence

MIQRLGSSLVKFKSKIAGAIWRNLDDKLTEVVSLKDFGAKGDGKTNDQDAVNAAMASGKRIDGAGATYKVSSLPDMERFYNTRFVWERLAGQPLYYVSKGFINGELYKITDNPYYNAWPQDKAFVYENVIYAPYMGSDRHGVSRLHVSWVKSGDDGQTWSTPEWLTALHPDYPTVNYHCMSMGVCRNRLFAMIETRTLAKNALTNCALWDRPMSRSLHLTGGITKAANQRYATIHVPDHGLFVGDFVNFSNSAVTGVSGDMAVATVIDKDNFTVLTPNQQTSDLNNAGKSWHMGTSFHKSPWRKTDLGLIPRVTEVHSFATIDNNGFVMGYHQGDVAPREVGLFYFPDAFNSPSNYVRRQIPSEYEPDASEPCIKYYDGVLYLITRGTRGDRLGSSLHRSRDIGQTWESLRFPHNVHHTTLPFAKVGDDLIMFGSERAENEWEAGAPDDRYKASYPRTFYARLNVNKWNADDIEWVNITDQIYQGDIVNSSVGVGSVVVKDSYIYYIFGGENHFNPMTYGDNKDKDPFKGHGHPTDIYCYKMQIANDNRVSRKFTYGATPGQAIPTFMGTDGVRIIPAPLHLAGEVVAADITVEHLTLKASTSADIRSEMLMEGEYGFIGKTIPTDNPTAQRVIISGGDGTAADKGAQITLHGAGSSTSRRAVYNANEHLFQSGAIMPYNDNVYPAGGPRNRFTTIHLTSDPIITSDATHKYGSQGIDEQVLKAWGKVYFKQYKLIGEMSRGVHHTHFGVLAQDIVAAFASEGLDAIDFGIVSFEEGQFGVRYSEILILEAAYTRYRLDKLEEMYAANKIS

Physico‐chemical properties

protein length:	811 AA
molecular weight:	90307,23070 Da
isoelectric point:	6,25908
aromaticity:	0,11221
hydropathy:	-0,39149

Domains

Domains [InterPro]

DC_1082
ATT
2–40

DC_1082 IPR024428 IPR024430 IPR030392

G3DSA:3.30.750.60
ATT
34–102

G3DSA:3.30.750.60 IPR001724 IPR001724 IPR024427 IPR001724 IPR001724 IPR001724 IPR024430 IPR036388

IPR036278
STR
38–550

IPR036278 SSF69349 cd10144

IPR024429
ENZ
39–102

IPR024429 G3DSA:2.120.10.10 IPR044914

IPR023366
STR
214–300

IPR023366 IPR001724 IPR001724

IPR001724
Unmapped
288–311

IPR001724

A0AAE8Y2R9

1 811

Architecture

ATT

STR

RBD

CHP

ATT 2-102 | STR 103-705 | RBD 706-778 | CHP 779-810 |

Legend: ATT STR RBD CBM LEC ENZ CHP LNK TAS TTP UNK Unmapped

Domains [InterPro]

Domain ID	Category	Cluster	Start	End	Layer	Name	Pref Zone	Confidence	Evidence	Support
DC_1082	ATT	DC_1082	2	40	Novel HMM	DC_1082	N-terminal	Low	Positional only	52 proteins / 52 hits
G3DSA:3.30.750.60	ATT	G3DSA:3.30.750.60	34	102	Merged direct domain	G3DSA:3.30.750.60	N-terminal	Low	Positional only	2 proteins / 2 hits
IPR036278	STR	IPR036278	38	550	Merged direct domain	Sialidase superfamily	Central	Low	Positional only	56 proteins / 56 hits
IPR024429	ENZ	DC_0802	39	102	InterPro cluster	Endosialidase, N-terminal extension domain	N-terminal	High	Text match	84 proteins / 84 hits
IPR024428	ENZ	DC_0114	103	545	InterPro cluster	Endosialidase, beta-propeller domain	Central	High	Text match	92 proteins / 92 hits
IPR001724	Unmapped	-	104	128	InterPro	Glycosyl hydrolase 58	-	-	-	-
G3DSA:2.120.10.10	STR	G3DSA:2.120.10.10	104	544	Merged direct domain	G3DSA:2.120.10.10	Central	Low	Positional only	42 proteins / 42 hits
IPR001724	Unmapped	-	169	197	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR024427	ENZ	DC_0382	214	296	InterPro cluster	Endosialidase, beta-barrel domain	Central	High	Text match	86 proteins / 86 hits
IPR023366	STR	IPR023366	214	300	Merged direct domain	ATP synthase subunit alpha, N-terminal domain-like superfamily	Central	Low	Positional only	44 proteins / 44 hits
IPR001724	Unmapped	-	288	311	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	358	384	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	436	462	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	492	516	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR024430	ENZ	DC_0521	546	705	InterPro cluster	Endosialidase, C-terminal domain	C-terminal	High	Text match	95 proteins / 95 hits
IPR024430	ENZ	DC_0521	546	690	InterPro cluster	Endosialidase, C-terminal domain	C-terminal	High	Text match	95 proteins / 95 hits
IPR044914	RBD	IPR044914	547	705	Merged direct domain	Endosialidase, C-terminal domain superfamily	C-terminal	Low	Positional only	39 proteins / 39 hits
SSF69349	STR	SSF69349	551	705	Merged direct domain	SSF69349	Central	Low	Positional only	153 proteins / 153 hits
IPR001724	Unmapped	-	598	624	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	630	657	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR030392	CHP	DC_0088	706	763	InterPro cluster	Intramolecular chaperone auto-processing domain	C-terminal	High	Text match	3502 proteins / 3959 hits
IPR036388	RBD	IPR036388	706	778	Merged direct domain	Winged helix-like DNA-binding domain superfamily	C-terminal	Low	Positional only	96 proteins / 96 hits
cd10144	CHP	DC_0088	706	810	InterPro cluster	cd10144	C-terminal	High	Text match	3502 proteins / 3959 hits

Tail Spike Domain Segmentation

This protein has been segmented into three structural domains: N-terminal, central domain, and C-terminal.

Domain Layout

N-terminal

Central

C-terminal

A0AAE8Y2R9

1 811

Domain	Start	End	Length (AA)	Confidence
N-terminal	1	48	48	0,9518
Central domain	49	282	235	0,7454
C-terminal	283	811	528	0,6046

Legend: N-terminal Central domain C-terminal

3D Structure with Domain Coloring

The structure is colored according to the domain segmentation: N-terminal (blue), Central (green), C-terminal (pink).

Domain Coloring

N-terminal
1-48

Central
49-282

C-terminal
283-811

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Escherichia phage ULINTec7 [NCBI]	2876731	Uroviricota > Caudoviricetes > Autographivirales > Molineuxvirinae > Vectrevirus
Host	Escherichia coli [NCBI]	562	cellular organisms > Bacteria > Pseudomonadati > Pseudomonadota > Gammaproteobacteria > Enterobacterales

Coding sequence (CDS)

No CDS data available.

Genome Context

Gene Ontology

	Description	Category	Evidence (source)
GO:0098015	virus tail	Cellular Component	IEA:UniProtKB-KW (UniProt)
GO:0016996	endo-alpha-(2,8)-sialidase activity	Molecular Function	IEA:InterPro (UniProt)

Tertiary structure

PDB ID

9eac9ac7b1dc2f0a2fa6eca8db384c55d1d0833813261957fcdb61674b3c251c

ColabFold

Source ColabFold

Method ColabFold

Resolution 0,2901

Oligomeric State monomer

Download PDB

Model Confidence

Very high
pLDDT > 90

High
90 > pLDDT > 70

Low
70 > pLDDT > 50

Very low
pLDDT < 50

Protein

Domains

Domains [InterPro]

Domains [InterPro]

Tail Spike Domain Segmentation

Tail Spike Domain Segmentation

3D Structure with Domain Coloring

Domain Coloring

Taxonomy

Coding sequence (CDS)

Coding sequence (CDS)

Genome Context

Genome Context

Gene Ontology

Tertiary structure

Predicted Aligned Error (PAE)

Model Confidence