Protein

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UniProt accession

A0A1D8EQA1 [UniProt]

Protein name

Endo-N-acetylneuraminidase

RBP type

Evidence Phold

Probability 1,00

TSP

Evidence DepoScope

Probability 1,00

TSP

Evidence RBPdetect2

Probability 0,94

Protein sequence

MSTTITNLPETSKVNGSDYLVLDQPDKTVKSTVSNFLTDTGVVLATQLKDISGATKYPELQMSRWRDEGDPRGWGAVGDGATDDTNAITQLLAAMPDGWIIDGRNLTFKVTTLPDISKFKNAAFVYERIVGQPLTYVSEGFFDGNLTKITDTPFYNAWTQDKTFVYDNVIYAPFMAGERHGVQNLHVAWVKSGDDGQTWSMPEWLTPIHPDYNASSANKVNYHCMSMGVCGNRLYAVIETRYLSNMRLKKAELWSRPMPYYRRPTGGITISSGSTTATIVLEKHGLKVGDAVNFSNSGATGVSGNMTVASVINKDTFTVTLASAATSNIDNTGTTWHFGTRFWDSPWEITELPDVAYSTNADLCVTETHSFTVIDDDNYTFAVGYHNGDVSPRRLGILYFNNAYSDPSSFTRRTISQEYADNAAEPCIKYYDGILYLTTRGTSTSAAGSTLAMSADLGENWNYLRFPNNVHHTNLPFAKVGNYLYIFGTERSFGEWEGEELDNRYKGTYPRTFMCKINVSAWPASLSDVQWFNITDQMYQGHIVNSACGVGSVCVKDGWLYYIFGGEDFLSPWSIGDNSKKLWYKHDGHPADLYSYRLKITEHDFVSRDFKYGATPNRTLPVSMGTDGVRHVSAPVTFDNDVQVHSLTVTGLEHDGTQQSAVRIKLDGDYGVVAKNVPIKNPSEQRLILCGGETPYVTDGSLLQLYGSNHTYPNRAVLYAPGGAYTQNNFMPYLDGQVALGGASNRWSEVYASTGTINTSDGTLKTKPTEIEDILLKAWEDIHVISYQWLSAIAEKGDSARIHFGVIAQDVRDILINYGLMDENSTDCKYAFLCYDEYPAMYDSVVTGQKEIPLFDDEGNVVIDEEGNPVTIVEDVVETIEIIPAGSRWGIRADQMFFIEMAYQRKKLKALEERLATLESK

Physico‐chemical properties

protein length:	921 AA
molecular weight:	102480,26850 Da
isoelectric point:	4,98764
aromaticity:	0,11401
hydropathy:	-0,33681

Domains

Domains [InterPro]

DC_0079
ATT
1–39

DC_0079 G3DSA:3.30.750.60 G3DSA:2.120.10.10 IPR044914 IPR030392

IPR036278
STR
75–606

IPR036278 SSF69349 cd10144

IPR024429
ENZ
76–142

IPR024429 IPR024428 IPR024430 IPR030392 G3DSA:3.30.2460.10 G3DSA:1.20.5.100

IPR001724
Unmapped
144–168

IPR001724 IPR001724 IPR024427 IPR001724 IPR001724 IPR001724 IPR001724 IPR001724 G3DSA:1.20.5.1240 Coil

IPR023366
STR
262–342

IPR023366

IPR001724
Unmapped
333–356

IPR001724

A0A1D8EQA1

1 921

Architecture

ATT

STR

CHP

RBD

CHP

RBD

ATT 1-39 | ATT 70-141 | STR 142-759 | CHP 760-772 | RBD 773-824 | CHP 825-891 | RBD 892-921

Legend: ATT STR RBD CBM LEC ENZ CHP LNK TAS TTP UNK Unmapped

Domains [InterPro]

Domain ID	Category	Cluster	Start	End	Layer	Name	Pref Zone	Confidence	Evidence	Support
DC_0079	ATT	DC_0079	1	39	Novel HMM	DC_0079	N-terminal	Low	Positional only	38 proteins / 38 hits
G3DSA:3.30.750.60	ATT	G3DSA:3.30.750.60	70	141	Merged direct domain	G3DSA:3.30.750.60	N-terminal	Low	Positional only	2 proteins / 2 hits
IPR036278	STR	IPR036278	75	606	Merged direct domain	Sialidase superfamily	Central	Low	Positional only	56 proteins / 56 hits
IPR024429	ENZ	DC_0802	76	142	InterPro cluster	Endosialidase, N-terminal extension domain	N-terminal	High	Text match	84 proteins / 84 hits
G3DSA:2.120.10.10	STR	G3DSA:2.120.10.10	142	600	Merged direct domain	G3DSA:2.120.10.10	Central	Low	Positional only	42 proteins / 42 hits
IPR024428	ENZ	DC_0114	143	600	InterPro cluster	Endosialidase, beta-propeller domain	Central	High	Text match	92 proteins / 92 hits
IPR001724	Unmapped	-	144	168	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	214	242	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR024427	ENZ	DC_0382	259	341	InterPro cluster	Endosialidase, beta-barrel domain	Central	High	Text match	86 proteins / 86 hits
IPR023366	STR	IPR023366	262	342	Merged direct domain	ATP synthase subunit alpha, N-terminal domain-like superfamily	Central	Low	Positional only	44 proteins / 44 hits
IPR001724	Unmapped	-	333	356	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	412	438	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	490	516	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	548	572	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR044914	RBD	IPR044914	603	759	Merged direct domain	Endosialidase, C-terminal domain superfamily	C-terminal	Low	Positional only	39 proteins / 39 hits
IPR024430	ENZ	DC_0521	603	759	InterPro cluster	Endosialidase, C-terminal domain	C-terminal	High	Text match	95 proteins / 95 hits
SSF69349	STR	SSF69349	607	759	Merged direct domain	SSF69349	Central	Low	Positional only	153 proteins / 153 hits
IPR001724	Unmapped	-	652	678	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR001724	Unmapped	-	684	711	InterPro	Glycosyl hydrolase 58	-	-	-	-
IPR030392	CHP	DC_0088	760	921	InterPro cluster	Intramolecular chaperone auto-processing domain	C-terminal	High	Text match	3502 proteins / 3959 hits
cd10144	CHP	DC_0088	760	907	InterPro cluster	cd10144	C-terminal	High	Text match	3502 proteins / 3959 hits
IPR030392	CHP	DC_0088	760	819	InterPro cluster	Intramolecular chaperone auto-processing domain	C-terminal	High	Text match	3502 proteins / 3959 hits
G3DSA:1.20.5.1240	RBD	G3DSA:1.20.5.1240	773	824	Merged direct domain	G3DSA:1.20.5.1240	C-terminal	Low	Positional only	1 proteins / 1 hits
G3DSA:3.30.2460.10	Unmapped	-	825	891	Gene3D	None	-	-	-	-
G3DSA:1.20.5.100	RBD	G3DSA:1.20.5.100	892	921	Merged direct domain	G3DSA:1.20.5.100	C-terminal	Low	Positional only	8 proteins / 8 hits
Coil	Unmapped	-	901	921	Coils	Coil	-	-	-	-

Tail Spike Domain Segmentation

This protein has been segmented into three structural domains: N-terminal, central domain, and C-terminal.

Domain Layout

N-terminal

Central

C-terminal

A0A1D8EQA1

1 921

Domain	Start	End	Length (AA)	Confidence
N-terminal	1	84	84	0,9786
Central domain	85	420	337	0,8867
C-terminal	421	921	500	0,5946

Legend: N-terminal Central domain C-terminal

3D Structure with Domain Coloring

The structure is colored according to the domain segmentation: N-terminal (blue), Central (green), C-terminal (pink).

Domain Coloring

N-terminal
1-84

Central
85-420

C-terminal
421-921

Taxonomy

	Name	Taxonomy ID	Lineage
Phage	Escherichia phage ESCO5 [NCBI]	1897495	Uroviricota > Caudoviricetes > Stephanstirmvirinae > Phapecoctavirus ESCO5 > Escherichia virus ESCO5
Host	No host information

Coding sequence (CDS)

No CDS data available.

Genome Context

Gene Ontology

	Description	Category	Evidence (source)
GO:0098015	virus tail	Cellular Component	IEA:UniProtKB-KW (UniProt)
GO:0016996	endo-alpha-(2,8)-sialidase activity	Molecular Function	IEA:InterPro (UniProt)

Tertiary structure

PDB ID

8eec8827c97ca71eb1bab97b071ab4699a9b0accd8b3ee0d2208235340e80f8f

ESMFold

Source ESMFold

Method ESMFold

Resolution 0,6785

Oligomeric State monomer

Download PDB

Model Confidence

Very high
pLDDT > 90

High
90 > pLDDT > 70

Low
70 > pLDDT > 50

Very low
pLDDT < 50

Protein

Domains

Domains [InterPro]

Domains [InterPro]

Tail Spike Domain Segmentation

Tail Spike Domain Segmentation

3D Structure with Domain Coloring

Domain Coloring

Taxonomy

Coding sequence (CDS)

Coding sequence (CDS)

Genome Context

Genome Context

Gene Ontology

Tertiary structure

Predicted Aligned Error (PAE)

Model Confidence