Protein

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UniProt accession
A0A8S5T497 [UniProt]
Protein name
DNA (cytosine-5-)-methyltransferase
RBP type
TSP
Evidence DepoScope
Probability 1,00
Protein sequence
MEQNKLTLGSLFDGSGGFPLGGLISGITPVWASEIEPFPIRVTTKRLPFMKHYGDVSRMDGGKIEPVDIITFGSPCQDMSIAGRREGLDGSRSSLFYEAVRIAKEMRCKTNGRYPRYIVWENVPGAFSSNKGADFQSVLEEVCSVKGYEIHTPRPERWPTAGEIVADDFSLAWRVFDAQYWGVPQRRKRIYLVADFAGGSAGKILFESEGVSGYTSQGFRSWQGAAGASEKGSGTAGCVCLNDQGGNRMDVTDGVTCTLRAEAHHPPCVMESAGFCTEHSAHSRSIGYEEETSPTLRAGTVPAAVYENHSQDTRYTGPLETAPTVNATYGMGGNNQPFVVETPKTLKIRSGCEGGGKGALIQDNKSATLGCNNDQTVFVPKVYGICSKQSHAMQSDNPHSGFYEADTSRCLDRGGGNPSCNQGGMAVVAVQGSMIGRSDKNGPQGSGVNEDVSFTLDATDRHAVAYGIDRATYNMGRNAKFGITVETEIEPTMVSKGPGAVGQPIYHSSKSSFHTNFTDDDVTETLVATDFKDPPTVSKEPDYIVRRLTPTECARLQGFPDWWCSNLETDEPTEEEIEFWTEVFETHRRVMGASSKPKSRNQIIKWLKDPHSDSAEYKMWGNGVALPNVCFVLSGIVYYAQLSGE
Physico‐chemical
properties
protein length:645 AA
molecular weight: 70198,52510 Da
isoelectric point:5,46634
aromaticity:0,08992
hydropathy:-0,46295

Domains

Domains [InterPro]
IPR029063
STR
1–217
IPR029063 G3DSA:3.90.120.10
IPR029063
STR
5–634
IPR029063
IPR001525
ATT
6–614
IPR001525
IPR001525
ATT
7–23
IPR001525 IPR050390 IPR001525
IPR001525
ATT
8–194
IPR001525
IPR018117
Unmapped
68–80
IPR018117 IPR001525 IPR001525
A0A8S5T497
1 645
Architecture
ATT
STR
ATT 1-614 | STR 615-634 |
Legend: ATT STR RBD CBM LEC ENZ CHP LNK TAS TTP UNK Unmapped

Tail Spike Domain Segmentation

Tail Spike Domain Segmentation

This protein has been segmented into three structural domains: N-terminal, central domain, and C-terminal.

Domain Layout
N-terminal
Central
C-terminal
A0A8S5T497
1 645
Domain Start End Length (AA) Confidence
N-terminal 1 227 227 0,1104
Central domain 228 538 312 0,8584
C-terminal 539 645 106 0,5867
Legend: N-terminal Central domain C-terminal
3D Structure with Domain Coloring

The structure is colored according to the domain segmentation: N-terminal (blue), Central (green), C-terminal (pink).

Domain Coloring
N-terminal
1-227
Central
228-538
C-terminal
539-645

Taxonomy

  Name Taxonomy ID Lineage
Phage Siphoviridae sp. ctm8l1
[NCBI] 		2827930 Uroviricota > Caudoviricetes >
Host No host information

Coding sequence (CDS)

Coding sequence (CDS)
Genbank protein accession
DAF57799.1 [NCBI]
Genbank nucleotide accession
BK032739 [NCBI]
CDS location
range 16272 -> 18209
strand +
CDS
ATGGAACAGAATAAACTGACCCTCGGCAGCCTGTTTGACGGCTCCGGCGGTTTTCCTTTAGGCGGCTTGATCTCCGGCATTACCCCTGTATGGGCATCGGAGATTGAGCCGTTTCCTATCCGGGTGACCACCAAGCGGCTGCCGTTTATGAAGCATTACGGCGATGTCTCCCGGATGGATGGCGGGAAGATTGAGCCGGTGGATATCATCACCTTCGGCTCACCCTGCCAGGACATGAGCATCGCAGGTCGGCGGGAGGGCTTGGACGGCTCCCGCTCCAGTCTTTTCTATGAAGCCGTCCGAATCGCAAAGGAAATGAGGTGCAAAACCAATGGCAGATATCCAAGATACATCGTCTGGGAGAACGTCCCTGGTGCGTTCAGCTCCAACAAGGGCGCGGACTTCCAGTCCGTCCTCGAAGAGGTCTGCTCGGTCAAGGGATACGAAATTCATACTCCTCGACCTGAGAGGTGGCCGACCGCCGGAGAGATCGTGGCAGATGATTTCAGTCTCGCATGGCGGGTATTTGATGCGCAGTACTGGGGAGTTCCCCAGCGCAGAAAACGTATCTACCTTGTCGCAGATTTTGCAGGCGGGAGTGCCGGAAAAATACTATTTGAGTCCGAAGGCGTGTCTGGGTATACTTCGCAGGGCTTCCGTTCGTGGCAAGGAGCTGCCGGAGCTTCTGAAAAAGGCTCTGGAACGGCAGGCTGCGTCTGCCTGAACGACCAGGGTGGAAACCGTATGGATGTAACGGACGGCGTCACCTGCACTCTCCGGGCAGAAGCCCATCATCCACCCTGCGTGATGGAATCGGCAGGATTTTGCACCGAGCATTCCGCGCACAGCCGCTCCATCGGTTACGAGGAGGAAACCTCTCCCACCCTCCGTGCCGGTACGGTGCCGGCGGCGGTCTATGAGAACCATAGCCAGGACACCAGATACACCGGCCCGTTGGAGACGGCCCCTACGGTCAACGCCACCTACGGCATGGGTGGGAACAACCAGCCCTTTGTGGTGGAGACGCCTAAGACGCTGAAGATCCGCTCCGGCTGTGAGGGTGGCGGCAAGGGCGCACTGATCCAGGACAACAAATCCGCCACGCTGGGCTGCAACAATGACCAGACGGTATTTGTGCCGAAGGTCTACGGCATCTGCTCCAAGCAGAGCCACGCCATGCAATCGGACAATCCGCACAGCGGTTTTTATGAAGCGGACACTTCCCGCTGTTTGGACAGGGGCGGCGGCAATCCCTCCTGCAACCAGGGCGGCATGGCTGTGGTGGCTGTGCAGGGTTCCATGATCGGAAGATCCGACAAGAACGGTCCCCAGGGCAGCGGCGTCAATGAGGATGTGTCCTTCACGCTGGATGCTACCGACCGTCATGCGGTAGCCTACGGAATCGACCGTGCCACATACAACATGGGACGGAATGCCAAGTTCGGAATCACGGTGGAAACAGAGATCGAGCCAACGATGGTGTCCAAAGGACCGGGAGCGGTCGGACAGCCTATCTATCATTCAAGCAAGAGTTCCTTTCACACCAATTTTACGGATGATGATGTGACGGAAACGTTGGTCGCTACAGATTTCAAAGATCCGCCTACCGTATCCAAGGAGCCTGACTACATCGTTCGCAGACTGACGCCTACCGAATGTGCCAGACTGCAAGGGTTCCCGGACTGGTGGTGTTCCAATTTAGAGACTGACGAACCGACCGAGGAAGAGATCGAGTTCTGGACGGAGGTGTTTGAGACACACCGGAGGGTCATGGGAGCTTCCTCCAAGCCGAAGAGCCGCAATCAGATCATCAAGTGGCTGAAAGACCCTCACTCCGATTCTGCGGAATACAAGATGTGGGGCAACGGCGTGGCGCTTCCCAACGTCTGTTTTGTGCTTTCCGGCATCGTGTACTATGCACAGTTATCCGGCGAATGA

Genome Context

Genome Context

Gene Ontology

Description Category Evidence (source)
GO:0003886 DNA (cytosine-5-)-methyltransferase activity Molecular Function IEA:UniProtKB-EC (UniProt)
GO:0003677 DNA binding Molecular Function IEA:TreeGrafter (UniProt)
GO:0032259 methylation Biological Process IEA:UniProtKB-KW (UniProt)
GO:0044027 negative regulation of gene expression via chromosomal CpG island methylation Biological Process IEA:TreeGrafter (UniProt)
GO:0099018 symbiont-mediated evasion of host restriction-modification system Biological Process IEA:UniProtKB-KW (UniProt)
GO:0052170 symbiont-mediated suppression of host innate immune response Biological Process IEA:UniProtKB-KW (UniProt)

Tertiary structure

PDB ID
342b09eab032deaa12e7cd263e826a93577afebc7cae33de91190529c52e0b03
ColabFold
Source ColabFold
Method ColabFold
Resolution 0,6414
Oligomeric State monomer
Download PDB
Model Confidence
Very high
pLDDT > 90
High
90 > pLDDT > 70
Low
70 > pLDDT > 50
Very low
pLDDT < 50